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pentobarbital will minimize the extent or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with sturdy CYP3A4 inducers is just not suggestedpentobarbital will lower the level or effect of alosetron by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Not known.Observe Ca